• Users Online: 231
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 39  |  Issue : 3  |  Page : 114-121

Antiplatelet antibodies in chronic hepatitis C patients: correlation with platelet count and viral load


1 Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Correspondence Address:
Abeer S Elhadidi
Department of Clinical Pathology, Faculty of Medicine, Alexandria University, PO Box 22758, Alexandria
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-1067.148232

Rights and Permissions

Background HCV associated thrombocytopenia is one of the most frequent manifestations of hepatitis C virus (HCV) infection; which typically worsens with progression of the liver disease and can become a major clinical complication that prevents chronic HCV patients from receiving the standard peg-interferon/ribavirin therapy. The aim of the present work was to study the role of anti-platelet antibodies in the pathogenesis of HCV-associated thrombocytopenia and to correlate it with the extent of thrombocytopenia, level of viremia, and ALT level in patients with chronic HCV infection. Patients and Methods This study was conducted on 200 patients with chronic HCV, divided into 2 groups, group I included 100 patients with normal platelet count (platelet count ≥150 × 109 /L), whereas group II included 100 patients with thrombocytopenia (platelet count <150 × 109 /L). Direct and indirect anti-platelet antibodies were detected by flowcytometry and immunofluorescence respectively. The results demonstrated statistically significant correlations between presence of anti-platelet antibodies and degree of thrombocytopenia, viral load, and the extent of the liver damage.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1212    
    Printed26    
    Emailed0    
    PDF Downloaded143    
    Comments [Add]    

Recommend this journal