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ORIGINAL ARTICLE
Year : 2017  |  Volume : 42  |  Issue : 4  |  Page : 148-154

Role of measurement of interleukin 10 in idiopathic (immune) thrombocytopenic purpura


1 Department of Hematology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Hematology & BMT Unit, El-Shiekh Zayed Specialized Hospital, Giza, Egypt

Correspondence Address:
Heba Tolba
Hematology & BMT Unit, El-Shiekh Zayed Specialized Hospital, Giza, 12555
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_26_17

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Aim Biological markers useful for defining newly diagnosed patient with immune thrombocytopenic purpura (ITP) who are likely to develop the chronic form of the disease are partially lacking. The purpose of this study was to assess the clinical role of a cytokine in patients with ITP and correlate its levels with different stages of the disease. Patients and methods A total of 20 patients with ITP at the onset stage, 40 patients with chronic ITP, and 30 healthy matched controls were enrolled in this study. Serum levels of interleukin 10 (IL-10) were measured in all patients using quantitative immunoenzymatic assays. Result Serum IL-10 levels were significantly higher in patients with an acute evolution of ITP than in either healthy controls or patients with chronic ITP. Conclusion IL-10 seems to predict the clinical course of ITP, as it is significantly higher at the onset of the disease in patients who obtain disease remission in less than 1 year.


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