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ORIGINAL ARTICLE
Year : 2018  |  Volume : 43  |  Issue : 4  |  Page : 179-183

Prognostic significance of BCL6 and KI67 in patients with chronic lymphocytic leukemia


1 Department of Hematology, Medical Research Institute, Faculty of Medicine, University of Alexandria, Alexandria, Egypt
2 Department of Hematology, Internal Medicine Department, Faculty of Medicine, University of Alexandria, Alexandria, Egypt

Correspondence Address:
Maha Mohamed Adel Elgammal
Department of Hematology, Medical Research Institute, Alexandria University, Alexandria
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_26_18

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Background Chronic lymphocytic leukemia (CLL) is a heterogeneous disease; its prognosis depends on the disease stage at diagnosis as well as the presence or absence of high-risk markers to determine the treatment strategy. Aim To evaluate the expression of BCL6 and Ki67 in patients with CLL and to assess their clinical prognostic significance in relation to other established prognostic markers such as Zeta-associated protein of 70-Kd (ZAP70) and β2 microglobulin (β2M). Participants and methods BCL6 and Ki67 were measured using flow cytometry in thirty newly diagnosed CLL patients who presented to the Hematology units in Alexandria Main University Hospital and the Medical Research Institute, Alexandria University, they were also measured in 20 healthy age-matched and sex-matched controls. Results A statistically significant difference was found between cases and controls for both BCL6 and Ki67 expressions (P<0.0001). Significantly positive correlations were found between both BCL6 and Ki67 expressions and the following parameters: Rai staging (P=0.000 and 0.000, respectively), serum marker lactate dehydrogenase (LDH) (P=0.001 and 0.000, respectively), β2M (P=0.005 and 0.000, respectively), and ZAP70 expression (P=0.000 and 0.000, respectively). Similarly, a positive significant correlation was found between BCL6 expression and Ki67 expression (P=0.000). Rai staging showed a significant positive correlation with β2M, LDH, and ZAP70 (P=0.000, 0.001, and 0.003, respectively). Conclusion BCL6 expression and Ki67 expressions were positively correlated with the established prognostic markers (clinical staging, LDH, β2M, and ZAP70), so both of them may be considered as prognostic factors in patients with CLL.


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