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ORIGINAL ARTICLE
Year : 2019  |  Volume : 44  |  Issue : 1  |  Page : 14-20

Iron-deficiency anemia as a risk factor for dyslipidemia in Egyptian patients


Department of Internal Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Emad A. Abd El-Hady
10 Ahmed Saman Street, Makram Ebeid Street, Nasr City, Cairo, 11762
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_42_18

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Introduction Iron is an important component of some enzymes involved in hepatic lipid metabolism. Several factors such as increased erythropoiesis leading to increased cholesterol demand may lead to hypocholesterolemia combined with anemia. Objective The aim of this study was to investigate the relationship between iron-deficiency anemia (IDA) and dyslipidemia in nonobese patients and to show the effect of iron therapy on their lipid profile. Patients and methods This study was conducted on 60 nonobese individuals selected from Ain Shams University Hospital. It comprised 40 patients with IDA (equally divided according to sex), who were assessed initially and after receiving 3 months of oral iron therapy regarding lipid and iron profiles, in addition to 20 normal individuals without anemia as a control group. All patients were submitted to full history and clinical examination in addition to fasting lipid profile and iron study profile. Results We found that patients with anemia especially male ones had higher lipid parameters compared with healthy nonanemic controls. However, after iron therapy, we found significant increase in hemoglobin (HB) levels and decrease in cholesterol, triglyceride, low-density lipoprotein, and very low-density lipoproteinlevels compared with pretherapy values. In patients with anemia, we found statistically significant negative correlations between the preiron therapy cholesterol levels on one hand and both of HB and ferritin on the other hand. Treatment of iron-deficiency corrected dyslipidemia significantly in the form of significant negative correlation between serum cholesterol level and HB. Conclusion IDA may be associated with increased cholesterol levels. When a course of iron therapy is taken, significant beneficial changes in lipid profile may occur, but the exact mechanism is still unclear. As serum lipid profile is affected by many factors, hence the variations of lipid concentration in IDA may not be related to iron deficiency by itself.


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