• Users Online: 601
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 44  |  Issue : 2  |  Page : 111-117

Outcome of reduced-intensity allogeneic stem cell transplantation in Egyptian patients with myelodysplastic syndromes


1 Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
2 Department of Clinical Pathology, Clinical Hematology Unit, Faculty of Medicine, Assiut University, Assiut, Egypt
3 Department of Internal Medicine, Clinical Hematology Unit, Faculty of Medicine, Assiut University, Assiut, Egypt
4 Department of Oncological Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
5 Department of Medical Oncology, South Cancer Institute, Assiut University, Assiut, Egypt

Correspondence Address:
Safinaz Hussein
Clinical Hematology, Department of Internal Medicine, Assiut University, Assiut, 71516
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_2_19

Rights and Permissions

Background Reduced-intensity conditioning for allogeneic stem cell transplantation (allo-SCT) is possible for patients with myelodysplasia syndrome (MDS) who are ineligible for high-dose myeloablative conditioning allo-SCT. Objective To determine the outcome of reduced-intensity allo-SCT in Egyptian patients with MDS. Patients and methods A total of 18 patients with MDS were included, and the median age was 39 years. The conditioning regimen consisted of fludarabine (150 mg/m2) and busulfan (8 mg/kg). All patients received mobilized peripheral blood stem cells. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. Results The Kaplan–Meier-estimated 2-year overall survival and disease-free survival were 49 and 33%, respectively. The Kaplan–Meier-estimated probability of relapse at 2 years was 43.5%. The Kaplan–Meier-estimated probability of nonrelapse mortality at 2 years was 43%, and severe acute GVHD and sepsis were the main causes of death. The Kaplan–Meier-estimated probabilities of acute and chronic GVHD were 31 and 20%, respectively. Conclusion Although reduced-intensity conditioning regimens allowed for decreased transplant-related toxicities and increased durable engraftments, their use was associated with a high incidence of relapse in patients with MDS.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed38    
    Printed2    
    Emailed0    
    PDF Downloaded9    
    Comments [Add]    

Recommend this journal