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ORIGINAL ARTICLE
Year : 2019  |  Volume : 44  |  Issue : 2  |  Page : 134-140

Influence of altitude in anemia and risk assessment for chronic obstructive pulmonary disease


1 Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, India
2 Biomaterials and Nanomedicine Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, India
3 Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, India
4 Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore; Department of Animal Science, Bharathidasan University, Tiruchirappalli, India

Correspondence Address:
Sangeetha Thangavelu
Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore–46, Tamil Naidu, 641 046
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_10_19

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Background Anemia is one of the most common blood disorders globally, affecting one-third of the world’s population, caused due to lack of iron in the human blood resulting in an abnormal hemoglobin range. Lung disorders are the third leading life-threatening disease worldwide, which is caused due to inflammation or injuries in the lungs or respiratory tract. Altitude increase is suspected to play a role in the induction and progression of both anemia and lung disorders. A point mutation SERPINA1 gene, a serine protease inhibitor, is directly linked with lung damage, has also been found to cause the anemic condition. Materials and methods The present study is aimed at analysis of variations of the biochemical parameters in both the diseases along with the altitudinal comparison, in order to predict the influence of altitude on them. The study was also aimed at depicting the association of anemia with lung disorders and hence SERPINA1 gene was examined for mutation to determine the risk for lung disorders. Results The biochemical and altitudinal comparison gave significant association, whereas, negative results were obtained in the genetic analysis. Conclusion All the obtained results clearly indicate that altitude has a major role in influencing the incidence and prevalence of anemia. It has also been found that all the anemic patients are not susceptible to lung disorders on a genetic basis.


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