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ORIGINAL ARTICLE
Year : 2019  |  Volume : 44  |  Issue : 3  |  Page : 168-174

Single nucleotide polymorphism in FCƔRIIa and FCƔRIIIa and its association with the incidence of childhood primary immune thrombocytopenia


1 Clinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
2 Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
3 Department of Community Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Correspondence Address:
Noha A Doudar
Faculty of Medicine, Beni-Suef University
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_7_18

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Introduction Immune thrombocytopenia purpura (ITP) is characterized by severe autoimmune destruction of platelets. Genetic factors play an important role in its pathogenesis. The objective of this study is to investigate the association of FCƔRIIa and FCƔRIIIa gene polymorphism with childhood ITP regarding the severity and response. Patients and methods A total of 55 pediatric patients with ITP and 55 age-matched and sex-matched healthy controls were enrolled in the study to detect the association between the polymorphisms and ITP. Genotyping of FCƔRIIa was performed using PCR-restriction fragment length polymorphism, and genotyping of FCƔRIIIa was performed via TaqMan 5’-allelic discrimination technique. Results Distribution of FCƔRIIa single nucleotide polymorphism (SNP) alleles revealed that the allele frequency distribution for children with ITP was 56.4 and 43.6% for H and R alleles, respectively, with no statistically significant differences when compared with control (P=0.891). The frequency distribution of FCƔRIIa genotypes of patients with ITP showed no statistically significant differences when compared with control (χ2=10.3, P=0.005). Regarding FCƔRIIIa SNP genotypes, the heterozygous mutant VF genotype was statistically higher in patient group compared with healthy control. Conclusion There is a role of heterozygous VF genotype and FCƔRIIIa V/F SNP in the pathogenesis of childhood ITP. No association between the development of ITP and FCƔRIIa gene polymorphism was found. Both FCƔRIIa R/H and FCƔRIIIa V/F are not related to severity of ITP or response to treatment.


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