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ORIGINAL ARTICLE
Year : 2019  |  Volume : 44  |  Issue : 4  |  Page : 237-245

Positive expression of FOXP1 protein as a good prognostic factor in childhood acute lymphoblastic leukemia: a retrospective study


1 Department of Clinical Pathology, Faculty of Medicine, Asyut University, Egypt
2 Department of Clinical Pathology, South Cancer Institute, Assiut University, Egypt

Correspondence Address:
Marwa Saad Mohamed
Department of Clinical Pathology, Faculty of Medicine, Assiut University
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_37_19

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Background Deficiency of FOXP1 in early B-lymphoid precursors results in a block at the transition of pro-B to pre-B-cell stage and severely reduces the peripheral mature B-cell compartment. Objective The objective of the current study was to detect the prognostic value of positive FOXP1 protein expression on acute lymphoblastic leukemia (ALL) in children and adults evaluated by disease-free survival (DFS) and overall survival and its relation with BCR-ABL fusion gene in those patient. Materials and methods A retrospective study was carried out on 50 bone marrow samples from fixed bone marrow aspirates taken from patients previously diagnosed with ALL at South Egypt Cancer Institute. They were classified into 25 BCR-ABL-positive samples and 25 BCR-ABL-negative samples. Results Positive expression of FOXP1 protein in B lymphocytes in patients with ALL was associated with better overall survival and DFS, especially in children. Coexistence of both FOXP1 and BCR-ABL proteins in the patients with ALL was associated with good prognosis than BCR-ABL-positive patients with negative expression of FOXP1. Conclusion The positive expression of FOXP1 protein in B lymphocytes in pediatric patients with ALL and its association with better overall survival and DFS indicate that FOXP1 protein expression in pediatric ALL is a good prognostic marker. Coexistence of both FOXP1 and BCR-ABL proteins in the patients with ALL appeared as a good prognostic factor.


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