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ORIGINAL ARTICLE
Year : 2020  |  Volume : 45  |  Issue : 1  |  Page : 1-7

CD62P and CD40 ligand in diabetic pregnant women


1 Department of Clinical Pathology, Faculty of Medicine, Minia University, Minia, Egypt
2 Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia, Egypt

Correspondence Address:
Nagwa I Okaily
Department of Clinical Pathology, Faculty of Medicine, Minia University, Minia, 61111
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_23_19

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Aim We evaluated the expression of CD62P and CD40 ligand in diabetic pregnant women to correlate between these parameters and hemostatic abnormalities and to evaluate the relationship of these parameters with the fetal outcome. Settings and design This is a prospective case–control study that included 60 patients: 40 diabetic pregnant women (patient group), who were subdivided into group Ia (20 pregnant women with preexisting diabetes) and group Ib (20 with gestational diabetes), and 20 apparently healthy, age-matched and sex-matched pregnant women (control group). Patients and methods Platelet activating markers (CD62P and CD40L) were measured using flow cytometry. Results A significant increase in CD40L and CD62P percentage in group I compared with group II was present (P<0.001). There were significant correlations between the groups Ia and Ib in percentages of both CD40L and CD62P (P=0.001). There was a significant increase in maternal complications in those with preexisting diabetes mellitus (60%) more than in those with gestational diabetes mellitus (10%) and significant positive correlations between CD40L and CD62P. Conclusion Expressions of CD62P and CD40 ligand are increased in diabetic pregnant women, and this means that platelet activation and aggregation play an important and possibly key role in fetal and maternal complications, whereas CD40L expression plays an important role in maternal complications.


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