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Year : 2020  |  Volume : 45  |  Issue : 1  |  Page : 23-27

Initially presented acute coronary syndrome: does D-dimer imply any clinical significance?

1 Departments of Cardiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Departments of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Yasmin N El-Sakhawy
Assisstant Professor Clinical Pathology Department, Ain Shams University, Egypt
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejh.ejh_40_19

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Background D-Dimer is an enzymatic degradation product that is formed as a result of breakdown of cross-linked fibrin clots by plasmin. The plasma level of D-dimer is vital for evaluating the patient’s fibrinolytic status. D-dimer testing was proven to be beneficial marker in the identification of deep vein thrombosis of the lower limbs and pulmonary embolism [16]. The relationship between the level of D-dimer levels & acute coronary syndrome is uncertain and conflicting. Aim The aim of this study was to assess D-dimer levels in patients presented to the emergency room (ER) with acute chest pain. Subjects and methods The first group involved those diagnosed with acute coronary syndrome (ACS); which included unstable angina pectoris [UA], non-ST elevated myocardial infarction [NSTEMI], ST-elevated myocardial infarction [STEMI]); the control group involved those diagnosed with non-cardiac chest pain. The serum levels of D-dimer, creatine kinase-MB (CK-MB) and troponin I (TPI) were assessed in the two groups. Results Levels of D-dimer, CK-MB and TPI was higher in the patient group. There were also higher D-dimer, CK-MB and TPI levels in the STEMI and NSTEMI patient subgroups as compared with the control group. Merely the D-dimer level was higher in the UA subgroup as compared with the control group. Conclusion D-dimer levels assessment seemed to be useful in the ER for identifying ACS patients and to predict mortality hazards in patients presenting with acute chest pain.

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