• Users Online: 39
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 45  |  Issue : 1  |  Page : 35-39

Wilms’ tumor gene (WT1) expression levels as prognostic marker in pediatric acute lymphoblastic leukemia


1 Department of Clinical Pathology, Alexandria Faculty of Medicine, Egypt
2 Department of Pediatric Oncology, Students Hospital, Alexandria, Egypt

Correspondence Address:
Neveen L Mikhael
Department of Clinical Pathology, Alexandria Faculty of Medicine, Alexandria, 21131, Egypt
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_30_19

Rights and Permissions

Background Wilms’ tumor gene (WT1) encodes a transcription factor that has a role in kidney development and malignancy. WT1 is shown to be overexpressed in most adult acute myeloid leukemias and hence is an adverse prognostic factor. Its use as a prognostic marker in childhood acute lymphoblastic leukemia (ALL) is controversial. Aim The aim was to study WT1 gene expression levels for diagnosis of ALL in a group of Egyptian children and to relate it to prognosis. Participants and methods This study was conducted on 140 children newly diagnosed as having ALL; assessment of WT1 gene was done by real-time PCR in bone marrow (BM) samples at diagnosis and at day 28 of treatment. Results WT1 gene expression was positive in 96 (68.6%) cases and negative in 44 (31.4%) cases. WT1 expression was related to aberrant expression of myeloid markers. There was a significant correlation between WT1 expression at diagnosis and at day 28 and minimal residual disease detected at day 28. No correlation was detected between outcome and WT1 level during follow-up. Conclusion WT1 gene expression is related to response to therapy as defined by day 28 minimal residual disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed222    
    Printed4    
    Emailed0    
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal