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ORIGINAL ARTICLE
Year : 2020  |  Volume : 45  |  Issue : 1  |  Page : 40-47

Value of assessment of factor XI in patients with myeloproliferative neoplasms with and without thrombotic events


1 Departments of Internal Medicine, Ain Shams University, Cairo, Egypt
2 Departments of Clinical Pathology, Ain Shams University, Cairo, Egypt

Correspondence Address:
Emad A Abdelhady
10 Ahmed Saman Street, from Makram Ebeid Street, Nasr City Cairo, 1199, Egypt
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejh.ejh_46_19

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Background Although high levels of factor XI and contact factors have been implicated as a risk factor for deep venous thrombosis and possibly cardiovascular disease in some cancers like prostatic cancer, the relationship between elevated factor XI activity and thrombosis in myeloproliferative neoplasm (MPN) is not established yet. Aim The aim was to study the possible relation between factor XI in patients with MPNs with and without thrombotic events in comparison with normal controls and the possible effect of its altered level to occurrence of such events. Patients and methods This is a cross-sectional study conducted in Ain Shams University Hospitals and included 50 patients with MPN. Patients were investigated to assess the relation between level of factor XI and thrombus formation. Results There was no statistically significant difference between the level of factor XI and thrombotic incidence in patients with MPN. Conclusion This study focusing on the contribution of factor XI to the thrombotic risk in patients with MPN showed that there was no link between the high levels of factor XI and the thrombotic risk in patients with MPN.


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