Year : 2014 | Volume
: 39 | Issue : 3 | Page : 128--133
The prognostic value of CXCR4 and pCXCR4 in B-lineage acute lymphoblastic leukemia in adults
Amina M Elnaggar1, Rania A Ghonaim1, Tarek A El-Gohary2, Maha Atfy1
1 Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt
2 Department of Medical Oncology & Hematology, Faculty of Medicine, Zagazig University, Egypt
Background CXC chemokine receptor 4 (CXCR4) is activated by phosphorylation (pCXCR4) and is essential for the migration of hematopoietic precursors to bone marrow. Data regarding the prognostic impact of CXCR4 in patients with B-acute lymphoblastic leukemia (B-ALL) are sparse and limited to the pediatric population.
Patients and methods Fifty adult patients with B-ALL were included in the study. CXCR4 was assessed by flow cytometry and pCXCR4 by immunocytochemistry. All patients received a hyper-CVAD regimen.
Results Thirty-one patients had positive CXCR4 expression, of whom only 18 (58%) had positive pCXCR4 expression. The complete response rate for patients with positive expression of pCXCR4 was significantly inferior to those with negative expression (61.1 vs. 93.7%; P < 0.01). In the multivariate analysis, pCXCR4 expression was associated with a worse disease-free survival ( P < 0.027) and overall survival (P < 0.024). Positive expression of pCXCR4 was not associated with an increased incidence of extramedullary disease or had any relation to the degree of maturity of B-ALL.
Conclusion The current study indicates that adult B-ALL patients with positive expression of pCXCR4 have an inferior response to chemotherapy, disease-free survival, and overall survival compared with patients with negative expression.
Department of Clinical Pathology, Hospitals of Zagazig University, PO Box 44519, Sharkeyia
|How to cite this article:|
Elnaggar AM, Ghonaim RA, El-Gohary TA, Atfy M. The prognostic value of CXCR4 and pCXCR4 in B-lineage acute lymphoblastic leukemia in adults.Egypt J Haematol 2014;39:128-133
|How to cite this URL:|
Elnaggar AM, Ghonaim RA, El-Gohary TA, Atfy M. The prognostic value of CXCR4 and pCXCR4 in B-lineage acute lymphoblastic leukemia in adults. Egypt J Haematol [serial online] 2014 [cited 2020 Jan 28 ];39:128-133
Available from: http://www.ehj.eg.net/article.asp?issn=1110-1067;year=2014;volume=39;issue=3;spage=128;epage=133;aulast=Elnaggar;type=0