The Egyptian Journal of Haematology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 39  |  Issue : 4  |  Page : 232--237

Quantitative assessment of MLAA-34 expression in a sample of Egyptian patients with acute myeloblastic leukemia


Magdy El-Bordiny1, Ashraf El-Ghandour2, Mona Wagdy Ayad1, Noha Abou-Diba1 
1 Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Department of Hematology, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Correspondence Address:
Mona Wagdy Ayad
9 Abd El Hamid El Deeb Street, Sarwat, Alex
Egypt

Background: MLAA-34 is a novel acute monocytic leukemia-associated antigen. Previous studies found that it might be an antiapoptotic factor and play a role in the carcinogenesis and the progression of leukemia, and its overexpression might be associated with an unfavorable presentation of acute myeloid leukemia (AML). Aim and objectives: The aim of this work was to study the expression of MLAA-34 in AML and its correlation with known prognostic parameters and the clinical outcome. Patients and methods: In 30 patients with de-novo AML compared with a control group of 25 age-matched and sex-matched individuals, MLAA-34 expression was assessed using quantitative real-time RT-PCR. Results and conclusion: Results revealed an overexpression of MLAA-34 in patients with AML-M5 compared with controls. Also, MLAA-34 expression was associated with a poor outcome and unfavorable presentation (a high leukocytic count and extramedullary disease). In conclusion, MLAA-34 may be used as a prognostic tool in AML, especially M5. Egyptian J Haematol 39:-0 © 2014 The Egyptian Society of Haematology.


How to cite this article:
El-Bordiny M, El-Ghandour A, Ayad MW, Abou-Diba N. Quantitative assessment of MLAA-34 expression in a sample of Egyptian patients with acute myeloblastic leukemia.Egypt J Haematol 2014;39:232-237


How to cite this URL:
El-Bordiny M, El-Ghandour A, Ayad MW, Abou-Diba N. Quantitative assessment of MLAA-34 expression in a sample of Egyptian patients with acute myeloblastic leukemia. Egypt J Haematol [serial online] 2014 [cited 2020 Jan 24 ];39:232-237
Available from: http://www.ehj.eg.net/article.asp?issn=1110-1067;year=2014;volume=39;issue=4;spage=232;epage=237;aulast=El-Bordiny;type=0