The Egyptian Journal of Haematology

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 41  |  Issue : 3  |  Page : 111--115

Lower Fas-associated phosphatase-1 expression predicted poor outcome in acute myeloid leukemia patients


Nahla F.A. Osman1, Walaa M.H. Alzobary2, Mohamed A.M. Samra3, Hala H Alsaid4, Iman A Eltounsi5 
1 Haematology Unit, Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Clinical Pathology, Shebin El Kom Teaching Hospital, Shebin El Kom, Egypt
3 Department of Haemato-Oncology, National Cancer Institute, Cairo, Egypt
4 Department of Biochemistry, National Liver Institute, Menoufia University, Menoufia, Egypt
5 Department of Clinical Pathology, Menoufia University, Menoufia, Egypt

Correspondence Address:
Nahla F.A. Osman
Haematology Unit, Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shebin El Kom
Egypt

Background Fas-associated phosphatase-1 (FAP-1) mediates tumor suppressor and tumor promoter effects through the inhibition of oncogenic tyrosine kinases and apoptosis, respectively. It was claimed responsible for the pathogenesis of some cancers; nevertheless, its role in acute myeloid leukemia (AML) is not clear. Patients and Methods FAP-1 expression was measured in 20 new AML patients and 12 apparently healthy individuals using real-time PCR. Results FAP-1 expression was significantly lower in AML patients compared with controls (P<0.001). Patients with relatively higher FAP-1 expression had significantly higher hemoglobin and platelets but lower white cell count (WCC) and lactic dehydrogenase (LDH) (P<0.001), thus reflecting lower tumor burden in this group. Patients’ response was assessed on day 28 after chemotherapy; we found that one of seven patients with FAP-1 expression up to 0.03945 achieved complete remission (CR) compared with eight of 13 patients with levels more than 0.03945. FAP-1 levels predicted the response in the subgroup with normal karyotype and in those with no FLT3-ITD as the majority of those with higher levels achieved CR (77.8 and 80%, respectively), whereas CR was seldom achieved in those with low levels. Conclusion Our data showed significantly reduced FAP-1 expression in AML patients. FAP-1 can be a useful tool in identifying patient’s risk in AML as the level of expression predicted the response.


How to cite this article:
Osman NF, Alzobary WM, Samra MA, Alsaid HH, Eltounsi IA. Lower Fas-associated phosphatase-1 expression predicted poor outcome in acute myeloid leukemia patients.Egypt J Haematol 2016;41:111-115


How to cite this URL:
Osman NF, Alzobary WM, Samra MA, Alsaid HH, Eltounsi IA. Lower Fas-associated phosphatase-1 expression predicted poor outcome in acute myeloid leukemia patients. Egypt J Haematol [serial online] 2016 [cited 2020 Sep 20 ];41:111-115
Available from: http://www.ehj.eg.net/article.asp?issn=1110-1067;year=2016;volume=41;issue=3;spage=111;epage=115;aulast=Osman;type=0