Figure 1 Clozapine is converted into a toxic metabolite. NADPH oxidase-generated superoxide is converted into hypochlorous acid by superoxide dismutase-dependent and myeloperoxidase-dependent reactions. This acid oxidizes clozapine (and other drugs) into metabolites (e.g. the nitrenium ion in case of clozapine), which interacts with sulfhydryl groups in the glutathione cycle. This may lead to the formation of haptens or to the depletion of the neutrophil of ATP. This leads to apoptosis and eventually to neutropenia. Adapted from [6,7]. Adaptations are themselves works protected by copyright. So in order to publish this adaptation, authorization must be obtained both from the owner of the copyright in the original work and from the owner of copyright in the translation or adaptation.